Paul Webster - Even with the availability of a variety of antibiotics, otitis media remains one of the major causes of morbidity and the most common cause of hearing loss in children.
The House Ear Institute seeks to understand the causes of persistent otitis media infections in infants and children and to find ways of improving diagnosis and treatment.
Such persistent infections may well be the result of bacterial biofilms forming in the middle ear. Biofilms have been broadly defined as multicellular assemblages of microorganisms and extracellular products attached to an abiotic or biotic surface. The extracellular products form a matrix, typically rich in sugar moieties, that confers protection from host immune responses, phagocytosis and antibiotic treatment.
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